Amputation and regeneration of limbs in the Axolotl (Ambystoma mexicanum)

作者:Liebsch Christina*; Reimers Kerstin; Strauss Sarah; Vogt Peter M; Mutschmann Frank
来源:Kleintierpraxis, 2013, 58(10): 505-511.
DOI:10.2377/0023-2076-58-505

摘要

Biological processes by which living creatures heal or regenerate damaged tissues comprise complex biochemical and cellular processes. In some species, remarkable. results in regeneration are accomplished. One example is the limb regeneration of urodeles, and in this particular case, the axolotl. An important prerequisite for the replacement of a lost limb is a local reaction of the stump tissue. For this reason, after a limb amputation, the wound tissue must not be closed by sutures, by which the inductive stimulus to build up wound epithelium is suppressed. In certain cases, amputation in the healthy tissue may be required for optimisation of the healing process. Appropriate anaesthesia when performing surgery in enervated tissue in these animals is the immersion into MS 222 (ethyl 3-aminobenzoate methanesulphonic acid; Finquel (R), Argent, USA). Disinfection and local anaesthesia are not indicated because they might provoke tissue necrosis.

  • 出版日期2013-10