Urea mediated 5-substituted-1H-tetrazole via [3+2] cycloaddition of nitriles and sodium azide

作者：Yakambram B; Shree A Jaya; Reddy L Srinivasula; Satyanarayana T; Naveen P; Bandichhor Rakeshwar^*

来源：Tetrahedron Letters, 2018, 59(5): 445-449.

DOI：10.1016/j.tetlet.2017.12.067

• Urea
• Cycloaddition
• Tetrazole
• Azide

A simple, new and convenient metal free procedure for the synthesis of 5-substituted 1H-tetrazoles using various nitriles and sodium azide in the presence of urea and acetic acid with good to high yields is developed. The reaction plausibly proceeds through in situ formation of urea azide active complex without toxic and/or expensive metal catalysts.

• 出版日期2018-1-31