Microbial networking in cancer: when two toxins collide

作者:Tomkovich Sarah; Jobin Christian*
来源:British Journal of Cancer, 2018, 118(11): 1407-1409.
DOI:10.1038/s41416-018-0101-2

摘要

A recent study by Dejea et al. has demonstrated that two enterotoxigenic bacteria frequently associated with sporadic colorectal cancer, Bacteroides fragilis and pks+Escherichia coli, are found together in biofilms on tissue from patients with familial adenomatous polyposis. In preclinical mouse models, these two bacteria and their corresponding toxins work synergistically to promote colon cancer.

  • 出版日期2018-5