Adipose tissue-resident immune cells: key players in immunometabolism

作者：Schipper Henk S; Prakken Berent; Kalkhoven Eric^*; Boes Marianne

来源：Trends in Endocrinology and Metabolism, 2012, 23(8): 407-415.

DOI：10.1016/j.tem.2012.05.011

• obesity
• adipose tissue
• inflammation
• immunometabolism
• energy-on-demand model

Adipose tissue (AT) plays a pivotal role in whole-body lipid and glucose homeostasis. AT exerts metabolic control through various immunological mechanisms that instigated a new research field termed immunometabolism. Here, we review AT-resident immune cells and their role as key players in immunometabolism. In lean subjects, AT-resident immune cells have housekeeping functions ranging from apoptotic cell clearance to extracellular matrix remodeling and angiogenesis. However, obesity provides bacterial and metabolic danger signals that mimic bacterial infection, and drives a shift in immune-cell phenotypes and numbers, classified as a prototypic T helper 1 (Th1) inflammatory response. The resulting AT inflammation and insulin resistance link obesity to its metabolic sequel, and suggests that targeted immunomodulatory interventions may be beneficial for obese patients.

• 出版日期2012-8