A Facile One-Pot Synthesis of 1,2,3-Tri- and 1,1,2,3-Tetrasubstituted Bis(guanidine)s from Bis(thiourea)s

作者：Vass Valentin; Dehmel Maximilian; Lehni Florian; Kretschmer Robert^*

来源：European Journal of Organic Chemistry, 2017, 2017(34): 5066-5073.

DOI：10.1002/ejoc.201700782

• Synthetic methods
• Desulfurization
• Hydrogen bonds
• Guanidines
• X-ray diffraction

A facile and efficient one-pot strategy for the preparation of 1,2,3-tri- and 1,1,2,3-tetrasubstituted bis(guanidine)s by starting from from readily available bis(thiourea)s has been successfully developed. The reaction provides products that contain a range of terminal and bridging groups. After a simple workup procedure, the products were obtained in analytically pure and in good to excellent yields.

• 出版日期2017-9-15