N-2-Modified 2-aminopurine ribonucleosides as minor-groove-modulating adenosine replacements in duplex RNA

作者：Peacock Hayden; Maydanovych Olena; Beal Peter A^*

来源：Organic Letters, 2010, 12(5): 1044-1047.

DOI：10.1021/ol100019r

Nucleoside analogs that project substituents into the minor groove when incorporated into duplex RNA perturb the binding of proteins and can affect base pairing specificity. The synthesis of 2-aminopurine ribonucleoside analogs and their phosphoramidites, their incorporation into duplex RNA, their postsynthetic modification via Cu-catalyzed azide-alkyne cycloaddition (CuAAC), and their effect on duplex stability and base pairing specificity are described.

• 出版日期2010-3-5