科研之友
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摘要
The role of oxidative stress in skeletal health is unclear. The present study investigated whether a high dietary intake of antioxidant nutrients (vitamins C and E, beta-carotene, animal-derived vitamin A, retinol equivalents, Zn and Se) is associated with a reduced risk of hip fracture in elderly Chinese. This 1:1 matched case-control study involved 726 elderly Chinese with hip fracture and 726 control subjects, recruited between June 2009 and May 2013. Face-to-face interviews were conducted to determine habitual dietary intakes of the above-mentioned seven nutrients based on a seventy-nine-item FFQ and information on various covariates, and an antioxidant score was calculated. After adjustment for potential covariates, dose-dependent inverse associations were observed between the dietary intake of vitamin C, vitamin E, b-carotene, and Se and antioxidant score and the risk of hip fracture (P for trend <= 0.005). The OR of hip fracture for the highest (v. lowest) quartile of intake were 0.39 (95% CI 0.28, 0.56) for vitamin C, 0.23 (95% CI 0.16, 0.33) for vitamin E, 0.51 (95% CI 0.36, 0.73) for beta-carotene, 0.43 (95% CI 0.26, 0.70) for Se and 0.24 (95% CI 0.17, 0.36) for the antioxidant score. A moderate-to-high dietary intake of retinol equivalents in quartiles 2-4 (v. 1) was found to be associated with a lower risk of hip fracture (OR range: 0.51-0.63, P< 0.05). No significant association was observed between dietary Zn or animal-derived vitamin A intake and hip fracture risk (P for trend >0.20). In conclusion, a higher dietary intake of vitamins C and E, b-carotene, and Se and a moderate-to-high dietary intake of retinol equivalents are associated with a lower risk of hip fracture in elderly Chinese.
- 出版日期2014-11-28
- 单位中山大学
