(1-3)-beta-D-Glucan Assay: A Review of its Laboratory and Clinical Application

作者：Wright William F^*; Overman Sue B; Ribes Julie A

来源：Laboratory Medicine, 2011, 42(11): 679-685.

DOI：10.1309/LM8BW8QNV7NZBROG

• (1-3)-beta-D glucan
• beta glucan assay
• invasive fungal infections

A new fungal surrogate marker, (1-3)-beta-D glucan, offers a noninvasive method for the potential surveillance and diagnosis of invasive fungal infections. Invasive fungal infections have long been associated with significantly high morbidity and mortality on hematology-oncology wards and recipients of either solid-organ or hematopoietic stem cell transplantation. The diagnoses of invasive fungal infections have historically been made difficult by the need for invasive methods. (1-3)-beta-D-glucan testing requires a minimally invasive sample that can be used to aid in the diagnosis of an invasive fungal infection as well as monitor the response to treatment. One disadvantage of (1-3)-beta-D-glucan testing is that a positive test alone lacks sufficient sensitivity and specificity for a definitive diagnosis. While formal guidelines for the use of (1-3)-beta-D-glucan testing are lacking, this chromogenic assay provides a new opportunity for testing at-risk populations. A review and recommendation for its laboratory and clinical application are provided.
Glossary
(1-3)-beta-D-glucan: A polysaccharide component of the cell wall of most fungi pyrogen test. An assay used to determine if a pharmaceutical or medical device intended for human use will stimulate fever.

• 出版日期2011-11