A novel synthesis of arylpyrrolo[1,2-a]pyrazinone derivatives

作者：Wang F^*; Wang JW; Zhang SF

来源：Molecules, 2004, 9(7): 574-582.

DOI：10.3390/90700574

• aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones
• synthesis
• anti-inflammation

Some aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinones were designed and prepared to study the Structure-Activity Relationships (SAR) of pyrrolo[1,2-a]pyrazinone derivatives. With methyl pyrrole-2-carboxylate as the starting material, the title compounds were prepared through N-alkylation and two novel cyclizations. Eleven aryl-2-methyl-1-pyrrolo[1,2-a]pyrazinone derivatives not previously reported in the literature are presented in this paper. Some of them show potent anti-inflammatory and analgesic activities.

• 出版日期2004-7
• 单位沈阳药科大学