No evidence of interaction between known lipid-associated genetic variants and smoking in the multi-ethnic PAGE population

作者：Dumitrescu Logan; Carty Cara L; Franceschini Nora; Hindorff Lucia A; Cole Shelley A; Buzkova Petra; Schumacher Fredrick R; Eaton Charles B; Goodloe Robert J; Duggan David J; Haessler Jeff; Cochran Barbara; Henderson Brian E; Cheng Iona; Johnson Karen C; Carlson Chris S; Love Shelly Anne; Brown Gentry Kristin; Nato Alejandro Q; Quibrera Miguel; Shohet Ralph V; Ambite Jose Luis; Wilkens Lynne R; Le Marchand Loic; Haiman Christopher A; Buyske Steven

来源：Human Genetics, 2013, 132(12): 1427-1431.

DOI：10.1007/s00439-013-1375-3

Genome-wide association studies (GWAS) have identified many variants that influence high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and/or triglycerides. However, environmental modifiers, such as smoking, of these known genotype-phenotype associations are just recently emerging in the literature. We have tested for interactions between smoking and 49 GWAS-identified variants in over 41,000 racially/ethnically diverse samples with lipid levels from the Population Architecture Using Genomics and Epidemiology (PAGE) study. Despite their biological plausibility, we were unable to detect significant SNP x smoking interactions.

• 出版日期2013-12