Aberrant Whole-Brain Functional Connectivity and Intelligence Structure in Children with Primary Nocturnal Enuresis

作者：Yu, Bing; Sun, Hongbin; Ma, Hongwei; Peng, Miao; Kong, Fanxing; Meng, Fanxing; Liu, Na; Guo, Qiyong^*

来源：PLos One, 2013, 8(1): e51924.

DOI：10.1371/journal.pone.0051924

• ATTENTION-DEFICIT/HYPERACTIVITY DISORDER
• DEFICIT HYPERACTIVITY DISORDER
• MOTOR CORTEX
• CORTICAL HUBS
• MRI
• DISCONNECTIVITY
• SINGLE
• MEMORY

Aim: To assess the potential relationship between intelligence structure abnormalities and whole-brain functional connectivity in children with primary nocturnal enuresis (PNE) with resting-state functional magnetic resonance imaging (fMRI) to provide insights into the association between these two seemingly unrelated conditions.
Methods: Intelligence testing and fMRI data were obtained from 133 right-handed children, including 67 PNE children (M/F, 39:28; age, 10.5 +/- 1.2 y) and 66 age-matched healthy controls (M/F, 37:29; age, 10.1 +/- 1.1 y). All intelligence tests were performed using the China-Wechsler Intelligence Scale for Children (C-WISC). Each subject's full intelligence quotient (FIQ), verbal IQ (VIQ), performance IQ (PIQ), and memory/caution (M/C) factor was measured and recorded. Resting state fMRI scans were performed on a 3.0-T MR scanner and post-processed using REST software. Comparisons of z-score correlation coefficients between distinct cerebral regions were used to identify altered functional connectivity in PNE children.
Results: The PNE group had normal FIQ, VIQ, and PIQ values, indicating no significant variation from the control group. However, the M/C factor was significantly lower in the PNE group. Compared to the control group, PNE children exhibited overall lower levels of functional connectivity that were most apparent in the cerebello-thalamo-frontal pathway. The M/C factor significantly correlated with z-scores representing connectivity between Cerebellum_Crus1_L and Frontal_Mid_R.
Conclusion: PNE children exhibit intelligence structure imbalance and attention deficits. Our findings suggest that cerebello-thalamo-frontal circuit abnormalities are likely to be involved in the onset and progression of attention impairment in PNE children.

• 出版日期2013-1-2
• 单位中国医科大学; 辽宁省人民医院