Cerebrospinal fluid levels of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in subacute sclerosing panencephalitis

作者：Ichiyama Takashi^*; Matsushige Takeshi; Siba Peter; Suarkia Dagwin; Takasu Toshiaki; Miki Kenji; Furukawa Susumu

来源：Journal of Infection, 2008, 56(5): 376-380.

DOI：10.1016/j.jinf.2008.02.014

• cerebrospinal fluid
• matrix metalloproteinase-9
• subacute sclerosing panencephalitis
• tissue inhibitor of metalloproteinase-1

Objectives: To investigate the brain inflammation and damage in subacute sclerosing panencephatitis (SSPE), the cerebrospinal fluid (CSF) concentrations of matrix metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1) were determined in SSPE patients.
Methods: CSF MMP-9 and TIMP-1 levels were measured in 23 patients with SSPE in Papua New Guinea by ELISA.
Results: CSF MMP-9 levels and MMP-9/TIMP-1 ratios of SSPE patients were significantly higher than controls (p < 0.001 and p = 0.005, respectively). There were no significant differences in CSF TIMP-1 levels between SSPE patients and controls.
Conclusions: Previous studies suggested that CSF MMP-9 levels reflect inflammatory damage to the brain. Our findings suggest that the MMP-9 Level. in CSF is an indicator of inflammatory damage to the brain in SSPE.

• 出版日期2008-5
• 单位河北医科大学