Meiotic recombination and genome evolution in plants

作者：Melamed Bessudo Cathy; Shilo Shay; Levy Avraham A

来源：Current Opinion in Plant Biology, 2016, 30: 82-87.

DOI：10.1016/j.pbi.2016.02.003

Homologous recombination affects genome evolution through crossover, gene conversion and point mutations. Whole genome sequencing together with a detailed epigenome analysis have shed new light on our understanding of how meiotic recombination shapes plant genes and genome structure. Crossover events are associated with DNA sequence motifs, together with an open chromatin signature (hypomethylated CpGs, low nucleosome occupancy or specific histone modifications). The crossover landscape may differ between male and female meiocytes and between species. At the gene level, crossovers occur preferentially in promoter regions in Arabidopsis. In recent years, there is rising support suggesting that biased mismatch repair during meiotic recombination may increase GC content genome-wide and may be responsible for the GC content gradient found in many plant genes.

• 出版日期2016-4