Antioxidative effects of the methanolic extract of Hibiscus asper leaves in mice

作者：Hritcu Lucian; Bild Veronica; Foyet Harquin Simplice; Ciobica Alin; Serban Ionela Lacramioara^*; Timofte Daniel; Anton Emil

来源：Romanian Biotechnological Letters, 2014, 19(3): 9376-9383.

• Hibiscus asper
• extract
• antioxidant
• mice

While Hibiscus asper Hook. f. (Malvaceae) is a traditional herb largely used in the tropical regions of Africa as a vegetable, potent sedative, tonic and restorative, anti-inflammatory and antidepressive drug, there is very few scientific data concerning its efficacy. This study was undertaken in order to evaluate the possible antioxidative effects of the methanolic extract of H. asper leaves in laboratory mice. The antioxidant activity of the methanolic extract of H. asper leaves (100 mg/kg, 200 mg/kg, 400 mg/kg and 800 mg/kg) was assessed through the determination of two antioxidant enzymes: superoxide dismutase (SOD) and glutathione peroxidase (GPX), as well as a lipid peroxidation marker (malondialdehyde - MDA) in adult male and female Swiss albino mice. In both laboratory mice's sexes, methanolic extract of H. asper leaves showed potent antioxidant activities. Chronic administration of the metha nolic extract (daily, for 3 weeks) significantly increased antioxidant enzyme activities (SOD and GPX) and reduced lipid peroxidation (MDA level) in mice temporal lobe homogenates, suggested antioxidant activity.
These results confirm the traditional claims and provide promising baseline information for the potential use of the methanolic extract of H. asper leaves as an antioxidant agent in the fight against brain oxidative stress.

• 出版日期2014-7