Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization

作者：van den Berg Linda M; Zijlstra Willems Esther M; Richters Cornelia D; Ulrich Magda M W; Geijtenbeek Teunis B H^*

来源：Cellular Immunology, 2014, 289(1-2): 49-54.

DOI：10.1016/j.cellimm.2014.03.007

• Keratinocytes
• Dectin-1
• Beta-glucans
• Proliferation
• Migration
• Wound healing

Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing.

• 出版日期2014-6