科研之友
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摘要
Purpose: To evaluate the efficacy and toxicity of leucovorin (LV) plus 5-fluorouracil (5-FU) combined with oxaliplatin every 2 weeks on previously untreated advanced colorectal cancer patients in Chinese population. Patients and methods: Forty-nine patients were enrolled to receive, entirely as inpatients, 2-weekly cycles of oxaliplatin 85 mg/m(2) i.v. over 2 hours on Day 1, together with leucovorin 200 mg/m(2) over 2 hours, 5-FU 400 mg/m(2), bolus, followed by a 22-hours infusion of 5-FU at 600 mg/m(2) Days 1-2 (FOLFOX4) every 2 weeks. Treatment was given until progression or unmanageable toxicity. In all, 49 patients received >= 1 oxaliplatin dose and a median of 7 treatment cycles (range 1 similar to 27 cycles). Results: Of the 45 eligible patients, 1 complete response (CR) and 18 partial responses (PRs) were observed for an overall response rate of 42.2 percent (95 percent confidence interval 26 similar to 56 percent). Median progression-free survival was 7.2 months (6.4 similar to 8.0) and median overall survival was 14.8 months (13.1 similar to 16.5). Six patients (12.2 percent) reported Grade 3 similar to 4 neutropenia. Thirty-one patients (62.3 percent) experienced Grade 1 similar to 3 neurotoxicity and only 5 patients (10.2 percent) experienced Grade 3 neurotoxicity. Conclusion: In our experience, FOLFOX4 regimen is active and well tolereated in patients with previously untreated advanced colorectal cancer in Chinese population.
- 出版日期2007-11
- 单位浙江大学
