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摘要
Objective Evidence suggests that vitamin D may protect against the onset of diabetes. However, the mechanisms underlying the role of vitamin D on glycaemic status are unclear and warrant further investigation. We sought to determine the relationship between serum 25-hydroxyvitamin D (25[OH]D) and glycaemic status among intermediate-to-high-risk patients scheduled for coronary angiography. %26lt;br%26gt;Methods Participants were 3316 male and female patients (mean +/- SD age, 62.7 +/- 10.6 years). Four categories were formed according to serum 25[OH]D levels. The association between serum 25[OH]D and diabetes was assessed using multi-variable logistic regression. %26lt;br%26gt;Results Fasting and 2 h post-load glucose, HbA1c and the HOMA-IR indices diminished with increasing serum 25[OH]D levels (P %26lt; 0.001). However, no associations were observed between insulin, pro-insulin or C-peptide and serum 25[OH]D concentrations. The pro-inflammatory markers IL-6 and hs-CRP also decreased considerably with higher vitamin D levels (P %26lt; 0.001). After full adjustment, those with optimal serum 25 [OH]D levels had a reduced odds for fasting diabetes (OR = 0.63; 95% CI, 0.46-0.86; P-trend = 0.01), 2 h post-load diabetes (OR = 0.46; 95% CI, 0.29-0.74; P-trend = 0.004), both fasting/2 h post-load diabetes (OR = 0.61; 95% CI, 0.42-0.87; P-trend = 0.001) and all of the combined hyperglycaemic states (OR = 0.68; 95% CI, 0.52-0.80; P-trend = 0.01). %26lt;br%26gt;Conclusions Higher serum 25[OH]D levels were associated with better glycaemic status and lower inflammation. Should these observations be confirmed in future studies, vitamin D supplementation may prove a useful adjunct in attenuating the onset of diabetes.
- 出版日期2013-8
- 单位河北医科大学
