Procollagen Type I and III Aminoterminal Propeptide Levels and Severity of Interstitial Lung Disease in Mexican Women With Progressive Systemic Sclerosis

作者：Gonzalez Lopez Laura; Rocha Munoz Alberto D; Olivas Flores Eva M; Garcia Gonzalez Araceli; Peguero Gomez Ana R; Flores Navarro Juan; Villa Manzano Alberto I; Zavaleta Muniz Soraya A; Salazar Paramo Mario; Mejia Mayra; Juarez Contreras Pablo; Vazquez del Mercado Monica; Cardona Munoz Ernesto G; Trujillo Hernandez Benjamin; Nava Zavala Arnulfo H; Gamez Nava Jorge I^*

来源：Archivos de Bronconeumologia, 2015, 51(9): 440-448.

DOI：10.1016/j.arbres.2014.06.018

• Progressive systemic sclerosis
• Interstitial lung disease
• Procollagen type I aminoterminal propeptide
• Procollagen type III aminoterminal propeptide
• High-resolution computed tomography

Background: Interstitial lung disease (ILD) is a frequent complication in progressive systemic sclerosis (SSc), being present in 25% to 90% of cases. Objectives: To evaluate whether serum levels of procollagen type I and III aminoterminal propeptide (PINP and PIIINP) correlate with severity and patterns of ILD in Mexican women with SSc.
Methods: Thirty three SSc patients were assessed for disease characteristics and anti-topoisomerase antibodies (topo and also underwent pulmonary function tests and high-resolution computed tomography (HRCT). Nineteen patients had ILD + SSc, and 14 had no lung involvement (no ILD-SSc); data were compared with those from 45 healthy controls. PINP and PIIINP were assessed in all 3 groups.
Results: Patients with SSc had higher PINP and PIIINP vs controls (P = .001, P < .001, respectively). Compared to no ILD-SSc patients, those with ILD + SSc had longer disease duration in years (P = .005), higher modified Rodnan skin score (P < .001), higher Health Assessment Questionnaire-Disability-Index scores (P < .001), higher topo I U/mL (P <.001), PINP (49.28 +/- 28.63 vs. 32.12 +/- 18.58 mu g/L, P = .05), and PIIINP (4.33 +/- 1.03 vs. 2.67 +/- 1.26 mu g/L, P < .001) levels. ILD severity based on total HRCT correlated with PINP (r = .388, P = .03) and PIIINP (P = .594, P < .001). On adjusted analysis, ILD severity was associated with disease duration (P = .037), PII1NP (P = .038), and topo I (P = .045).
Conclusions: PINP and PIIINP are useful markers for severe ILD + SSc, suggesting they could play a role in the follow-up of this complication in SSc.

• 出版日期2015-9