Anti-Androgenic Activity of Icarisid II from Epimedium Herb in Prostate Cancer LNCaP Cells

作者：Miura Yoko; Oyama Masayoshi^*; Iguchi Kazuhiro; Ito Tetsuro; Baba Misako; Shikama Yuji; Usui Shigeyuki; Hirano Kazuyuki; Iinuma Munekazu; Mikamo Hiroshige

来源：Journal of Nutritional Science and Vitaminology, 2015, 61(2): 201-204.

DOI：10.3177/jnsv.61.201

• epimedium herb
• anti-androgenic activity
• icarisid II
• flavonoid glycoside

Anti-androgens are regarded as potential therapeutic agents for the treatment of prostate cancer. We determined that an epimedium herb (EH) extract exhibited anti-androgenic activity in a luciferase assay using androgen receptor-positive prostate cancer LNCaP cells. Nine EH-derived flavonoids were examined. The results identified icarisid II as a very potent anti-androgenic EH-derived flavonoid. A quantitative RT-PCR analysis confirmed that the flavonol suppressed the expression of the androgen-responsive KLK3 gene.

• 出版日期2015-4