alpha-Lipoic acid treatment prevents cystine urolithiasis in a mouse model of cystinuria

作者：Zee Tiffany; Bose Neelanjan; Zee Jarcy; Beck Jennifer N; Yang See; Parihar Jaspreet; Yang Min; Damodar Sruthi; Hall David; O'Leary Monique N; Ramanathan Arvind; Gerona Roy R; Killilea David W; Chi Thomas; Tischfield Jay; Sahota Amrik; Kahn Arnold; Stoller Marshall L^*; Kapahi Pankaj^*

来源：Nature Medicine, 2017, 23(3): 288-290.

DOI：10.1038/nm.4280

Cystinuria is an incompletely dominant disorder characterized by defective urinary cystine reabsorption that results in the formation of cystine-based urinary stones. Current treatment options are limited in their effectiveness at preventing stone recurrence and are often poorly tolerated. We report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3a1(-/-) mouse model of cystinuria by increasing the solubility of urinary cystine. These findings identify a novel therapeutic strategy for the clinical treatment of cystinuria.

• 出版日期2017-3
• 单位rutgers