Protease signalling: the cutting edge

作者：Turk Boris^*; Turk Dusan; Turk Vito

来源：The EMBO Journal, 2012, 31(7): 1630-1643.

DOI：10.1038/emboj.2012.42

• cathepsin
• inhibitor
• protease
• regulation
• signal transduction

Protease research has undergone a major expansion in the last decade, largely due to the extremely rapid development of new technologies, such as quantitative proteomics and in-vivo imaging, as well as an extensive use of in-vivo models. These have led to identification of physiological substrates and resulted in a paradigm shift from the concept of proteases as protein-degrading enzymes to proteases as key signalling molecules. However, we are still at the beginning of an understanding of protease signalling pathways. We have only identified a minor subset of true physiological substrates for a limited number of proteases, and their physiological regulation is still not well understood. Similarly, links with other signalling systems are not well established. Herein, we will highlight current challenges in protease research. The EMBO Journal (2012) 31, 1630-1643. doi: 10.1038/emboj.2012.42; Published online 24 February 2012

• 出版日期2012-4-4