Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort

作者：Cramer Daniel W; Fichorova Raina N; Terry Kathryn L; Yamamoto Hidemi; Vitonis Allison F; Ardanaz Eva; Aune Dagfinn; Boeing Heiner; Braendstedt Jenny; Boutron Ruault Marie Christine; Chirlaque Maria Dolores; Dorronsoro Miren; Dossus Laure; Duell Eric J; Gram Inger T; Gunter Marc; Hansen Louise; Idahl Annika; Johnson Theron; Khaw Kay Tee; Krogh Vittorio; Kvaskoff Marina; Mattiello Amalie; Matullo Giuseppe; Merritts Melissa A; Nodin Bjorn; Orfanos Philippos

来源：Cancer Epidemiology Biomarkers & Prevention, 2018, 27(7): 790-804.

DOI：10.1158/1055-9965.EPI-17-0744

Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (FOC) risk has not been fully defined.
Methods: CA15.3, CA125, and IgC1 antibodies against them were measured in 806 women who developed FAN; and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression.
Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower antiCA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA In antibodies were associated with higher risk for mutinous IOC occurring >= 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both.
Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types.
Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC.

• 出版日期2018-7