Phytochemical constituents from dietary plant Citrus hystrix

作者：Sadasivam Mathusalini; Kumarasamy Chandraprakash; Thangaraj Arasakumar; Govindan Mani; Kasirajan Gayathri; Vijayan Viswanathan; Devadasan Velmurugan; Chia-Her Lin; Madhusudhanan Gogul Ramnath; Ramaraj Thirugnanasampandan; Palathurai Subramaniam Mohan^*

来源：Natural Product Research, 2018, 32(14): 1721-1726.

DOI：10.1080/14786419.2017.1399386

• Pyranoflavones
• Citrus hystrix
• antioxidant
• -amylase
• acetylcholinesterase inhibitory activities
• cytotoxicity

Chemical investigation of the fruit peel of dietary plant Citrus hystrix offered two new flavones 5,6,4-trihydroxypyranoflavone I and 5,4-dimethyl-6-prenylpyranoflavone XIII besides 11 known compounds. The structures of all compounds were elucidated with the aid of suitable analytical methods like 1D, 2D-NMR, mass and single crystal X-ray analysis. An X-ray crystal study of compound II was done for the first time and the compounds I-VI, XI and XII are hitherto not reported from this plant. Biological studies revealed that compound I found to have a good antidiabetic and antiacetylcholinesterase activities meanwhile compounds II, III and V showed a significant free radical scavenging ability as well as antioxidant capacity. In addition, compounds I, IV, V and VI showed cytotoxicity against U87, A549 and MCF-7 cells. Overall, the new compound I showed valuable bioactive properties. Due to insufficient quantity of compound XIII, biological studies were not done.
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• 出版日期2018