A pharmacokinetic and residual study of sulfadiazine/trimethoprim in mandarin fish (Siniperca chuatsi) with single- and multiple-dose oral administrations

作者：Wang, W.; Luo, L.; Xiao, H.; Zhang, R.; Deng, Y.; Tan, A.; Jiang, L.^*

来源：Journal of Veterinary Pharmacology and Therapeutics, 2016, 39(3): 309-314.

DOI：10.1111/jvp.12279

• SULFADIAZINE-TRIMETHOPRIM
• LIQUID-CHROMATOGRAPHY
• WITHDRAWAL TIME
• BIOAVAILABILITY
• ORMETOPRIM
• PIGS

A pharmacokinetic and tissue residue study of sulfadiazine combined with trimethoprim (SDZ/TMP=5/1) was conducted in Siniperca chuatsi after single- (120mg/kg) or multiple-dose (an initial dose of 120mg/kg followed by a 5-day consecutive dose of 60mg/kg) oral administrations at 28 degrees C. The absorption half-life (t(1/2)), elimination half-life (t(1/2)), volume of distribution (V-d/F), and the total body clearance (Cl-B/F) for SDZ and TMP were 4.3 +/- 1.7 to 6.3 +/- 1.8h and 2.4 +/- 1.0 to 3.9 +/- 0.9h, 25.9 +/- 4.5 to 53.0 +/- 5.6h and 11.8 +/- 3.5 to 17.1 +/- 3.4h, 2.34 +/- 0.78 to 3.67 +/- 0.99L/kg and 0.39 +/- 0.01 to 1.33 +/- 0.57L/kg, and 0.03 +/- 0.01 to 0.06 +/- 0.01L/kg<bold>h and </bold>0.02 +/- 0.01 to 0.05 +/- 0.01L/kg<bold>h</bold>, respectively, after the single dose. The elimination half-life (t(1/2)) and mean residue time (MRT) for SDZ and TMP were 68.8 +/- 7.8 to 139.8 +/- 12.3h and 34.0 +/- 5.5 to 56.1 +/- 6.8h, and 99.3 +/- 6.1 to 201.7 +/- 11.5h and 49.1 +/- 3.5 to 81.0 +/- 5.1h, respectively, after the multiple-dose administration. The daily oral SDZ/TMP administration might cause a high tissue concentration and long t(1/2), thereby affecting antibacterial activity. The withdrawal time for this oral SDZ/TMP formulation (according to the accepted guidelines in Europe for maximum residue limits, <0.1mg/kg of tissues for sulfonamides, and <0.05mg/kg for TMP) should not be <36days for fish.

• 出版日期2016-6
• 单位中国水产科学研究院珠江水产研究所