Deciphering intracellular targets of organochalcogen based redox catalysts

作者:Schneider Thomas; Muthukumar Yazh; Hinkelmann Bettina; Franke Raimo; Doering Mandy; Jacob Claus; Sasse Florenz*
来源:Medchemcomm, 2012, 3(7): 784-787.
DOI:10.1039/c2md20049j

摘要

Traditionally, the activity of organochalcogen based redox catalysts in cancer cells has been associated with the increase of ROS levels. Using a phenotype guided approach we were able to identify tubulin and actin as targets of tellurium containing redox catalysts. This is the first detection of a defined intracellular target of such compounds.

  • 出版日期2012-7