Asian dust exposure triggers acute myocardial infarction

作者：Kojima Sunao^*; Michikawa Takehiro; Ueda Kayo; Sakamoto Tetsuo; Matsui Kunihiko; Kojima Tomoko; Tsujita Kenichi; Ogawa Hisao; Nitta Hiroshi; Takami Akinori

来源：European Heart Journal, 2017, 38(43): 3202-3208.

DOI：10.1093/eurheartj/ehx509

• Asian dust
• Acute myocardial infarction
• Chronic kidney disease

To elucidate whether Asian dust is associated with the incidence of acute myocardial infarction (AMI) and to clarify whether patients who are highly sensitive to Asian dust will develop AMI.
Twenty-one participating institutions located throughout Kumamoto Prefecture and capable of performing coronary intervention were included in the study. Data for ground-level observations of Asian dust events were measured at the Kumamoto Local Meteorological Observatory. Data collected between 1 April 2010 and 31 March 2015 were analysed, and 3713 consecutive AMI patients were included. A time-stratified case-crossover design was applied to examine the association between Asian dust exposure and AMI. The occurrence of Asian dust events at 1 day before the onset of AMI was associated with the incidence of AMI [odds ratio (OR), 1.46; 95% confidence interval (CI), 1.09-1.95] and especially, non-ST-segment elevation myocardial infarction was significant (OR 2.03; 95% CI, 1.30-3.15). A significant association between AMI and Asian dust was observed in patients with age 75 years, male sex, hypertension, diabetes mellitus, never-smoking status, and chronic kidney disease (CKD). However, Asian dust events had a great impact on AMI onset in patients with CKD (P < 0.01). A scoring system accounting for several AMI risk factors was developed. The occurrence of Asian dust events was found to be significantly associated with AMI incidence among patients with a risk score of 5-6 (OR 2.45; 95% CI: 1.14-5.27).
Asian dust events may lead to AMI and have a great impact on its onset in patients with CKD.

• 出版日期2017-11-14