Does the BAFF dysregulation play a major role in the pathogenesis of systemic lupus erythematosus?

作者：Binard Aymeric; Le Pottier Laeitia; Saraux Alain; Devauchelle Pensec Valerie; Pers Jacques Olivier; Youinou Pierre^*

来源：Journal of Autoimmunity, 2008, 30(1-2): 63-67.

DOI：10.1016/j.jaut.2007.11.001

• systemic lupus erythematosus
• BAFF
• B lymphocyte

Given the prominent role currently assigned to B lymphocytes in systemic lupus erythematosus, it is not surprising that the B cell activity factor belonging to the tumor necrosis factor family (BAFF) is involved in its pathogenesis. This cytokine is produced in excess, and inserted into its receptors on the surface of circulating B cells. Up-regulation of BAFF is most likely to lead to breach of tolerance by aberrant survival of B cells directed to the self. Trials aimed at blocking BAFF have thus been set out. Yet the results are awaited.

• 出版日期2008-3