Heavy Metal Bioaccumulation in an Atypical Primitive Neuroectodermal Tumor of the Abdominal Wall

作者：Roncati Luca^*; Gatti Antonietta Morena; Capitani Federico; Barbolini Giuseppe; Maiorana Antonio; Palmieri Beniamino

来源：Ultrastructural Pathology, 2015, 39(4): 286-292.

DOI：10.3109/01913123.2015.1013655

• Aluminum
• bioaccumulation
• bismuth
• Ewing's sarcoma/primitive euroectodermal tumor
• heavy metals
• microanalysis
• scanning electron microscope

Heavy metals are able to interfere with the function of vital cellular components. Besides in trace heavy metals, which are essential at low concentration for humans, there are heavy metals with a well-known toxic and oncogenic potential. In this study, for the first time in literature, we report the unique adulthood case of an atypical primitive neuroectodermal tumor of the abdominal wall, diagnosed by histology and immunohistochemistry, with the molecular hybridization support. The neoplasia occurred in a patient chronically exposed to a transdermal delivery of heavy metal salts (aluminum and bismuth), whose intracellular bioaccumulation has been revealed by elemental microanalysis.

• 出版日期2015