Acute lymphoblastic leukaemia in a child with systemic lupus erythematosus

作者：Gokce M; Bulus D; Bilginer Y; Gumruk F; Be**as N; Cetin M^*

来源：Lupus, 2012, 21(8): 910-913.

DOI：10.1177/0961203312436859

• Acute lymphoblastic leukaemia
• azathioprine
• childhood
• myelodysplasia
• systemic lupus erythematosus

Haematological involvement of systemic lupus erythematosus (SLE) - which ranges from the well-described haemolytic anaemia to macrophage activation syndrome - has a large impact on both morbidity and mortality. On the other hand, association between haematological malignities and SLE - in terms of pathophysiology and molecular genetics - is an obscure entity which has not been clarified evidently to date. Herein, we present a six-year-old female with the diagnosis of SLE who developed acute lymphoblastic leukaemia following a period of myelodysplasia. It could possibly be coincidental; however, persistent cytopenia, prominent dysplasia on bone marrow smears and azathioprine treatment may be considered as possible triggers for the development of leukaemia in the present case. Lupus (2012) 21, 910-913.

• 出版日期2012-7