A New Method for High-Yield Cyclopalladation of Primary and Secondary Amines. Atom-Efficient Open-to-Air Inexpensive Synthesis of Buchwald-Type Precatalysts

作者：Vicente Jose^*; Saura Llamas Isabel; Oliva Madrid Maria Jose; Garcia Lopez Jose Antonio

来源：Organometallics, 2011, 30(17): 4624-4631.

DOI：10.1021/om200464s

A new method for high-yield cyclopalladation of primary and secondary amines involving the corresponding ammonium triflates, instead of the amines generally employed, is reported. The method is applied for the synthesis of Buchwald-type precatalysts [Pd(C,N-C6H4CH2CH(R')NHR-2)X(phosphine)] that can be easily prepared by reaction of Pd(OAc)(2), 1 equiv of the ammonium triflate [PhCH2CH(R')NH2R]OTf, and an excess of NaX and then treating the resulting complexes [Pd-2(C,N-C6H4CH2CH(R')NHR-2)(2)(mu-X)(2)] with the appropriate phosphine. This new method has several advantages over Buchwald's reported synthesis.

• 出版日期2011-9-12