A PGC-1 Tale: Healthier Intestinal Stem Cells, Longer Life

作者:Zhou Yi; Lu Tinglin; Xie Ting*
来源:Cell Metabolism, 2011, 14(5): 571-572.
DOI:10.1016/j.cmet.2011.10.005

摘要

PGC-1 regulates energy homeostasis and mitochondrial activity. In this issue, Rera et al. (2011) show that dPGC-1 overexpression in Drosophila intestinal stem cells and their immediate progeny extends organismal life span and protects against age-related loss of intestinal homeostasis and integrity, thereby establishing a link between mitochondria, tissue stem cells, and aging.