Association between apolipoprotein E4 genotype and human immunodeficiency virus-associated dementia in younger adults starting antiretroviral therapy in South Africa

作者：Joska John A^*; Combrinck Marc; Valcour Victor G; Hoare Jacqueline; Leisegang Felicity; Mahne Anna Cecilia; Myer Landon; Stein Dan J

来源：Journal of NeuroVirology, 2010, 16(5): 377-383.

DOI：10.3109/13550284.2010.513365

• AIDS dementia complex
• amnestic disorders apolipoprotein E
• cognitive disorders delirium dementia

It is not known whether the apolipoprotein E (ApoE) epsilon 4 allelic variant is associated with human immunodeficiency virus (HIV)-associated dementia (HAD) in a South African population, where HIV clade C is predominant ApoE genotyping was performed on 144 participants in a larger study of HIV associated neurocognitive disorders (HAND) There was a lower frequency of the epsilon 2 and epsilon 3 alleles in the HIV-positive group, compared to a group of 300 community based newborn infants There were no differences in ApoE genotype across different categories of HAND The epsilon 4 allelic variant was less common in individuals with HAD than in those without HAD These findings suggest that the epsilon 4 allelic variant in HIV-positive individuals is not associated with the development of HAD in Southern Africa Journal of Neuro Virology (2010) 16, 377-383

• 出版日期2010-10