Brain activity during source memory retrieval in young, middle-aged and old adults

作者：Cansino Selene; Trejo Morales Patricia; Estrada Manilla Cinthya; Humberto Pasaye Alcaraz Erick; Aguilar Castaneda Erika; Salgado Lujambio Perla; Luisa Sosa Ortiz Ana

来源：Brain Research, 2015, 1618: 168-180.

DOI：10.1016/j.brainres.2015.05.032

• Episodic memory
• Source memory
• Aging
• Functional magnetic resonance imaging

We investigated neurofunctional changes associated with source memory decline across the adult life span using functional magnetic resonance imaging (fMRI). Young, middle-aged and old adults carried out a natural/artificial judgment of images of common objects that were randomly presented in one of the quadrants of the screen. At retrieval, the images were displayed at the center of the screen and the participants judged whether each image was new or old and, if old, they indicated in which quadrant of the screen the image had originally been presented. Comparing the items associated with correct versus incorrect source judgments revealed that no regions showed greater activity in young adults than in middle-aged adults; however, in young and middle-aged adults the activity in the left hippocampus and left anterior temporal cortex was of greater magnitude than in the older adults. Several regions also exhibited greater activity in young adults than in old adults. These results suggest that in middle age the recollection neural network, assessable by fMRI, is still preserved.

• 出版日期2015-8-27