A Glimpse of Structural Biology through X-Ray Crystallography

作者：Shi Yigong^*

来源：Cell, 2014, 159(5): 995-1014.

DOI：10.1016/j.cell.2014.10.051

Since determination of the myoglobin structure in 1957, X-ray crystallography, as the anchoring tool of structural biology, has played an instrumental role in deciphering the secrets of life. Knowledge gained through X-ray crystallography has fundamentally advanced our views on cellular processes and greatly facilitated development of modern medicine. In this brief narrative, I describe my personal understanding of the evolution of structural biology through X-ray crystallography-using as examples mechanistic understanding of protein kinases and integral membrane proteins-and comment on the impact of technological development and outlook of X-ray crystallography.

• 出版日期2014-11-20
• 单位清华大学