A Prospective Cohort Study of the Effect of Depot Medroxyprogesterone Acetate on Detection of Plasma and Cervical HIV-1 in Women Initiating and Continuing Antiretroviral Therapy

作者：Day Summer; Graham Susan M; Masese Linnet N; Richardson Barbra A; Kiarie James N; Jaoko Walter; Mandaliya Kishorchandra; Chohan Vrasha; Overbaugh Julie; McClelland R Scott^*

来源：JAIDS: Journal of Acquired Immune Deficiency Syndromes , 2014, 66(4): 452-456.

DOI：10.1097/qai.0000000000000187

• hormonal contraception
• HIV-1
• antiretroviral therapy
• DMPA

Depot medroxyprogesterone acetate (DMPA) use among HIV-1-infected women may increase transmission by increasing plasma and genital HIV-1 RNA shedding. We investigated associations between DMPA use and HIV-1 RNA in plasma and cervical secretions. One hundred two women initiated antiretroviral therapy, contributing 925 follow-up visits over a median of 34 months. Compared with visits with no hormonal contraception exposure, DMPA exposure did not increase detection of plasma (adjusted odds ratio: 0.81, 95% confidence interval: 0.47 to 1.39) or cervical HIV-1 RNA (adjusted odds ratio: 1.41, 95% confidence interval: 0.54 to 3.67). Our results suggest that DMPA is unlikely to increase infectivity in HIV-positive women who are adherent to effective antiretroviral therapy.

• 出版日期2014-8-1