Mathematical modeling of gonadotropin-releasing hormone signaling

作者:Pratap Amitesh; Garner Kathryn L; Voliotis Margaritis; Tsaneva Atanasova Krasimira; McArdle Craig A*
来源:Molecular and Cellular Endocrinology, 2017, 449(C): 42-55.
DOI:10.1016/j.mce.2016.08.022

摘要

Gonadotropin-releasing hormone (GnRH) acts via G-protein coupled receptors on pituitary gonadotropes to control reproduction. These are Gq-coupled receptors that mediate acute effects of GnRH on the exocytotic secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), as well as the chronic regulation of their synthesis. GnRH is secreted in short pulses and GnRH effects on its target cells are dependent upon the dynamics of these pulses. Here we overview GnRH receptors and their signaling network, placing emphasis on pulsatile signaling, and how mechanistic mathematical models and an information theoretic approach have helped further this field.

  • 出版日期2017-7-5