A Clinical Study of HBsAg-Activated Dendritic Cells and Cytokine-Induced Killer Cells During the Treatment for Chronic Hepatitis B

作者：Ma Y J; He M; Han J A; Yang L; Ji X Y^*

来源：Scandinavian Journal of Immunology, 2013, 78(4): 387-393.

DOI：10.1111/sji.12097

Abstract
We aim to study the therapeutic effects of HBsAg-activated DCs and cytokine-induced killer (CIK) cells as adoptive immunotherapy in patients with Chronic Hepatitis B (CHB). Autologous HBsAg-activated DC-CIK cells were infused into patients with CHB to evaluate their effect on HBV-DNA, HBsAg, ALT, etc. The viral load in the treatment group decreased significantly (P < 0.001), while that in the control group did not decrease (P > 0.05). Twenty-one patients (63.6% efficiency) in the treatment group had a viral response (>= 2 log decrease in viral load), while four patients (14.8% efficiency) from the control group had a viral response. There were significant differences in the viral responses of the two groups (the control group 63.6% versus the control group 14.8%, P < 0.001). We concluded that the immunity was enhanced after HBsAg activation in DCs and CIK cells. Reinfusion of autologous HBsAg-activated DC-CIK cells inhibited HBV proliferation in 21 of 33 (63.6%) patients.

• 出版日期2013-10
• 单位河南大学