Antimalarial polyoxygenated cyclohexene derivatives from the roots of Uvaria cherrevensis

作者：Lekphrom Ratsami; Kanokmedhakul Kwanjai; Schevenels Florian; Kanokmedhakul Somdej^*

来源：Fitoterapia, 2018, 127: 420-424.

DOI：10.1016/j.fitote.2018.01.018

• Uvaria cherrevensis
• Annanoceae
• Polyoxygenated cyclohexene
• Antimalarial
• Cytotoxicity

Three new polyoxygenated cyclohexene derivatives named cherrevenisyls A and B (1 and 2), and ellipeiopsol E (3), along with fifteen known compounds, were isolated from the roots of Uvaria cherrevensis. Their structures were determined by spectroscopic methods including 2D NMR techniques and mass spectrometry. The absolute configurations of 1 and 2 were assigned. Compounds 1, 2 and 5 showed antimalarial activity against Plasmodium falciparum with IC50 ranging from 3.34-7.34 mu g/mL. Compounds 5-18 exhibited cytotoxicity against three cancer cell lines (KB, MCF-7 and NCI-H187) with IC50 values in ranging from 1.26-49.03 mu g/mL.

• 出版日期2018-6