Asymmetric Synthesis of trans--Lactams by a Kinugasa Reaction on Water

作者：Chen, Zhenling; Lin, Lili; Wang, Min; Liu, Xiaohua^*; Feng, Xiaoming

来源：Chemistry - A European Journal, 2013, 19(23): 7561-7567.

DOI：10.1002/chem.201204373

• asymmetric catalysis
• -lactams
• diamine ligands
• Kinugasa reaction
• water chemistry

The asymmetric Kinugasa reaction was performed on pure water for the first time without the need for any organic co-solvents. In contrast to most asymmetric Kinugasa reactions, trans--lactams were obtained as the major products in good yields, enantioselectivities, and diastereoselectivities (up to 90% yield, 98% ee, and >99:1 d.r.). This reaction is atom-economical, environmentally friendly, and affords synthetically useful but challenging products.

• 出版日期2013-6
• 单位四川大学