A Facile Route to Ortho-Hydroxyanilnes through an Ir-III-Catalyzed Direct C-H Amidation of 2-Phenoxypyridines

作者:Wang, Lianhui; Yang, Zi; Yang, Mengqi; Tian, Miaodou; Kuai, Changsheng; Cui, Xiuling*
来源:Chemistry-An Asian Journal, 2017, 12(19): 2634-2643.
DOI:10.1002/asia.201701028

摘要

A highly efficient and regioselective Ir-III-catalyzed C-H amidation of 2-phenoxypyridines has been developed by using sulfonyl azides as an amino source. The amidated products were provided in good-to-excellent yields with broad functional-group tolerance. Furthermore, the 2-pyridyl moiety in the amidated products could be readily removed, thus offering an efficient route to synthetically useful ortho-hydroxyanilnes, which are important building blocks in organic synthesis.