Anaesthetic and cardiorespiratory effects of a constant rate infusion of fentanyl in isoflurane-anaesthetized sheep

作者：Funes Francisco J^*; del Mar Granados Maria; Morgaz Juan; Navarrete Rocio; Fernandez Sarmiento Andres; Gomez Villamandos Rafael; Munoz Pilar; Quiros Setefilla; Carrillo Jose M; Lopez Villalba Ignacio; Dominguez Juan M

来源：Veterinary Anaesthesia and Analgesia, 2015, 42(2): 157-164.

DOI：10.1111/vaa.12216

• anaesthesia
• cardiopulmonary
• fentanyl
• isoflurane
• sheep

ObjectiveTo determine the anaesthetic and cardiorespiratory effects of a constant rate infusion of fentanyl in sheep anaesthetized with isoflurane and undergoing orthopaedic surgery.
Study designProspective, randomised, blinded' controlled study.
AnimalsTwenty healthy sheep (weight mean 41.1SD 4.5kg).
MethodsSheep were sedated with intravenous (IV) dexmedetomidine (4gkg(-1)) and morphine (0.2mgkg(-1)). Anaesthesia was induced with propofol (1mgkg(-1)minute(-1) to effect IV) and maintained with isoflurane in oxygen and a continuous rate infusion (CRI) of fentanyl 10gkg(-1)hour(-1) (group F) or saline (group P) for 100minutes. The anaesthetic induction dose of propofol, isoflurane expiratory fraction (Feiso) required for maintenance and cardiorespiratory measurements were recorded and blood gases analyzed at predetermined intervals. The quality of recovery was assessed. Results were compared between groups using t-tests or Mann-Whitney as relevant.
ResultsThe propofol induction dose was 4.7 +/- 2.4mgkg(-1). Feiso was significantly lower (by 22.6%) in group F sheep than group P (p=0). Cardiac index (mean +/- SDmLkg(-1)minute(-1)) was significantly (p=0.012) lower in group F (90 +/- 15) than group P (102 +/- 35). Other measured cardiorespiratory parameters did not differ statistically significantly between groups. Recovery times and recovery quality were statistically similar in both groups.
Conclusions and clinical relevanceFentanyl reduced isoflurane requirements without clinically affecting the cardiorespiratory stability or post-operative recovery in anaesthetized sheep undergoing orthopaedic surgery.

• 出版日期2015-3