摘要
Mechanistic models that synthesize pharmacological and (patho) physiological process information provide a rich basis for the characterization of drug action. However, the underlying clinical data are often simplified in a manner that does not allow models to fully elucidate the structure of the drug effect. In this article, we describe data-simplification strategies that are in routine use to describe disease symptoms and compare them with a model developed for handling the true complexities of the data.
- 出版日期2010-8