Approaches to Simultaneous Analysis of Frequency and Severity of Symptoms

作者:Plan E L; Karlsson K E; Karlsson M O*
来源:Clinical Pharmacology & Therapeutics, 2010, 88(2): 255-259.
DOI:10.1038/clpt.2010.118

摘要

Mechanistic models that synthesize pharmacological and (patho) physiological process information provide a rich basis for the characterization of drug action. However, the underlying clinical data are often simplified in a manner that does not allow models to fully elucidate the structure of the drug effect. In this article, we describe data-simplification strategies that are in routine use to describe disease symptoms and compare them with a model developed for handling the true complexities of the data.

  • 出版日期2010-8