A bridging SF/Alg composite scaffold loaded NGF for spinal cord injury repair

作者：Jiao, Genlong; Pan, Yongqin; Wang, Cunchuang^*; Li, ZhaoXia^*; Li, Zhizhong; Guo, Rui^*

来源：Materials Science and Engineering: C , 2017, 76: 81-87.

DOI：10.1016/j.msec.2017.02.102

• Silk fibroin
• Scaffold
• Alginate microspheres
• Nerve growth factor
• Spinal cord injury

Neurons loss and axons degeneration after spinal cord injury (SCI) gradually give rise to result in functional motor and sensory impairment. A bridging biomaterial scaffold that allows the axons to grow through has been investigated for the repair of injured spinal cord. In this study, we introduced a silk fibroin (SF)-based neurobridge as scaffold enriched with/without nerve growth factor (NGF) that can be utilized as a therapeutic approach for spinal cord repair. NGF released from alginate (Alg) microspheres on SF scaffold (SF/Alg composites scaffolds) to the central lesion site of SCI significantly enhanced the sparing of spinal cord tissue and increased the number of surviving neurons. This optimal multi-disciplinary approach of combining biomaterials, controlled-release microspheres and neurotrophic factors offers a promising treatment for the injured spinal cord.

• 出版日期2017-7-1
• 单位暨南大学