Anti leukemic alpha-pyrone derivatives from the endophytic fungus Alternaria phragmospora

作者：Metwaly Ahmed M; Fronczek Frank R; Ma Guoyi; Kadry Hazem A; El Hela Atef A; Mohammad Abd Elsalam I; Cutler Stephen J; Ross Samir A^*

来源：Tetrahedron Letters, 2014, 55(24): 3478-3481.

DOI：10.1016/j.tetlet.2014.04.085

• Anti leukemic
• alpha-Pyrone derivatives
• Alternaria phragmospora
• Endophytic fungi

Four new (1-4) and two known (5 and 6) alpha-pyrone derivatives have been isolated from Alternaria phragmospora, an endophytic fungus from Vinca rosea, leaves. The isolated compounds were chemically identified to be 5-butyl-4-methoxy-6-methyl-2H-pyran-2-one (1), 5-buty1-6-(hydroxymethyl)-4-methoxy2H-pyran-2-one (2), 5-(1-hydroxybuty1)-4-methoxy-6-methy1-2H-pyran-2-one (3), 4-methoxy-6methy1-5-(3-oxobuty1)-2H-pyran-2-one (4), 5-(2-hydroxyethyl)-4-methoxy-6-methyl-2H-pyran-2-one (5), and 5-[(2E)-but-2-en-1-y1]-4-methoxy-6-methyl-2H-pyran-2-one (6). Compounds 2 and 4 showed moderate antileukemic activities against HL60 cells with IC50 values of 2.2 and 0.9 mu M and against K562 cells with IC50 values of 4.5 and 1.5 mu M, respectively.

• 出版日期2014-6-11