Age-adjusted glycated albumin accurately reflects blood glucose in patients with neonatal diabetes mellitus: comparison with calculated glycated albumin determined by past blood glucose concentrations

作者：Suzuki Shigeru^*; Furuya Akiko; Oshima Miho; Amamiya Satoshi; Nakao Atsushi; Wada Keiko; Okuhara Koji; Hayano Satoshi; Imamoto Aya; Matsuo Kumihiro; Tanahashi Yusuke; Azuma Hiroshi; Koga Masafumi

来源：Annals of Clinical Biochemistry, 2016, 53(1): 117-123.

DOI：10.1177/0004563215589382

• Neonatal diabetes mellitus
• glycated albumin
• glycaemic control indicator

BackgroundGlycated albumin is a useful glycaemic control indicator for neonatal diabetes mellitus. However, glycated albumin concentrations in infants are lower than those in adults and increase in an age-dependent manner. Based on our investigation of non-diabetic subjects, we proposed the possibility that the reference range for adults may be used regardless of age, provided that age-adjusted glycated albumin is employed. In the present study, we evaluate the usefulness of age-adjusted glycated albumin in neonatal diabetes mellitus patients.
MethodsSix neonatal diabetes mellitus patients (four patients with permanent neonatal diabetes mellitus and two patients with transient neonatal diabetes mellitus) were included. Measured glycated albumin or age-adjusted glycated albumin was compared to calculated glycated albumin, which was determined using calculation formulae we had reported based on past blood glucose over the 50 days before measurement of glycated albumin.
ResultsMeasured glycated albumin was significantly lower than calculated glycated albumin (20.54.9% versus 28.2 +/- 6.1%; p<0.0001), whereas age-adjusted glycated albumin was equivalent to calculated glycated albumin, showing no significant difference (27.5 +/- 6.8% versus 28.2 +/- 6.1%). Measured glycated albumin concentrations in patients with transient neonatal diabetes mellitus in remission were lower than the reference range for adults, whereas age-adjusted glycated albumin concentrations were within the reference range for adults.
ConclusionWe demonstrated that age-adjusted glycated albumin concentrations were consistent with calculated glycated albumin. Age-adjusted glycated albumin is therefore a useful glycaemic control indicator for neonatal diabetes mellitus patients.

• 出版日期2016-1