An efficient one-pot protocol for regioselective synthesis of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c] pyridazine-5(6H)-ones

作者：Khalafy Jabbar^*; Rimaz Mehdi; Rabiei Hossein; Panahi Leila

来源：Journal of Sulfur Chemistry, 2013, 34(4): 395-406.

DOI：10.1080/17415993.2012.745126

• pyrimido[4
• 5-c]pyridazines
• regioselective
• one-pot
• arylglyoxal
• thiobarbituric acid

A series of 3-aryl-6,8-dialkyl-7-thioxo-7,8-dihydropyrimido[4,5-c]pyridazine-5(6H)-one derivatives have been regioselectively synthesized via the one-pot three-component reaction of 1,3-dimethylthiobarbituric acid and 1,3-diethylthiobarbituric acid with various arylglyoxals in the presence of hydrazinium dihydrochloride in warm ethanol. These new substituted pyrimidopyridazines may be potential monoamine oxidase inhibitors.
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• 出版日期2013-8-1