Decrease in Diversity of Propionibacterium acnes Phylotypes in Patients with Severe Acne on the Back

作者：Dagnelie Marie Ange; Corvec Stephane; Saint Jean Melanie; Bourdes Valerie; Nguyen Jean Michel; Khammari Amir; Dreno Brigitte^*

来源：Acta Dermato-Venereologica, 2018, 98(2): 262-267.

DOI：10.2340/00015555-2847

• acne
• P. acnes phylotypes
• clonal complexes
• SLST-types

Propionibacterium acnes, a major member of normal skin microbiota, is subdivided into 6 phylotypes: IA1, IA2, IB, IC, II and III. This study investigated P. acnes subgroups on the face and back in patients with severe acne and in healthy controls. In 71.4% of patients with severe acne, P. acnes phylotypes were identical on the face and back, whereas this was the case in only 45.5% of healthy controls. The healthy group carried phylotypes IA1 (39.1%) and II (43.4%), whereas the acne group carried a high predominance of IA1 (84.4%), especially on the back (95.6%). In addition, the single-locus sequence typing (SLST) method revealed A1 to be the predominant type on the back of patients with acne, compared with a wide diversity in the healthy group. We report here that severity of acne on the back is associated with loss of diversity of P. acnes phylotype, with a major predominance of phylotype IA1. The change in balance of cutaneous P. acnes subgroups might be an inducing factor in the activation of P. acnes, which could trigger inflammation.

• 出版日期2018-2