Adolescent weight and height are predictors of specific non-Hodgkin lymphoma subtypes among a cohort of 2,352,988 individuals aged 16 to 19 years

作者：Leiba Merav^*; Leiba Adi; Keinan Boker Lital; Avigdor Abraham; Derazne Estela; Levine Hagai; Kark Jeremy D

来源：Cancer, 2016, 122(7): 1068-1077.

DOI：10.1002/cncr.29792

• adolescence
• epidemiology
• height
• non-Hodgkin lymphoma (NHL)
• obesity
• risk factors

BACKGROUNDThe age-adjusted annual incidence of non-Hodgkin lymphoma (NHL) has risen worldwide. This trend may be affected by the secular increase in height and the sharp upswing in adolescent overweight; these drive increased insulinlike growth factor 1 and chronic inflammation, which may play an etiologic role. This study examined the association of the body mass index (BMI) and height of adolescents with NHL subtypes, which have been insufficiently evaluated.
METHODSHealth-related data on 2,352,988 Israeli adolescents, aged 16 to 19 years, who were examined between 1967 and 2011 were linked to the Israel National Cancer Registry to derive the NHL incidence up to December 31, 2012 (4021 cases). Cox proportional hazards modeling was used to estimate the multivariate-adjusted hazard ratio (HR) for NHL subtypes associated with the BMI and height of adolescents.
RESULTSAdolescent overweight and obesity were associated with an HR of 1.25 (95% confidence interval [CI], 1.13-1.37; P=1.14x10(-5)) for NHL in comparison with normal weight. There was a graded association of height with NHL (P=4.29x10(-9)), with the tallest adolescents (95th percentile vs 25th to<50th percentiles [US Centers for Disease Control and Prevention]) exhibiting an HR of 1.28 (95% CI, 1.04-1.56). Marginal zone lymphoma, primary cutaneous lymphoma (PCL), and diffuse large B-cell lymphoma (DLBCL) showed the strongest associations for overweight/obesity, and DLBCL and PCL showed the strongest associations for height.
CONCLUSIONSThe findings of this large cohort study add to the growing body of evidence showing that higher body weight and taller stature during adolescence are associated with an increased risk of NHL and may modestly contribute to its increasing incidence. Further studies are needed to elucidate the mechanisms linking anthropometric measures and NHL risk. Cancer 2016;122:1068-1077. (c) 2016 American Cancer Society This large cohort study adds to the growing body of evidence showing that higher body weight and taller stature, especially during adolescence and young adulthood, may increase the risk of non-Hodgkin lymphoma. The biological mechanisms by which weight and height during adolescence influence the future risk of developing specific non-Hodgkin lymphoma subtypes need to be determined.

• 出版日期2016-4-1