Assessment of aortic stiffness among patients with systemic lupus erythematosus and rheumatoid arthritis by magnetic resonance imaging

作者：Karp Galia; Wolak Arik; Baumfeld Yael; Bar Am Nina; Novack Victor; Wolak Talya; Fuchs Lior; Shalev Aryeh; Shelef Ilan; Abu Shakra Mahmoud^*

来源：International Journal of Cardiovascular Imaging, 2016, 32(6): 935-944.

DOI：10.1007/s10554-016-0851-y

• Systemic lupus erythematosus
• Rheumatoid arthritis
• Aortic distensibility
• Pulse wave velocity
• Magnetic resonance imaging

To evaluate aortic stiffness by MRI in female patients with systemic lupus erythematosus (SLE) or rheumatoid arthritis (RA) in comparison to controls. We measured aortic strain, distensibility and pulse wave velocity (PWV) by MRI in 30 SLE patients, 31 RA patients and 53 matched controls. Mean PWV in SLE and RA patients were higher in comparison to controls (9.2 +/- 4.4 vs. 7.6 +/- 3.0 m/s, p = 0.04) and (6.2 +/- 2.3 vs. 5.4 +/- 1.7, p = 0.04) respectively. Aortic distensibility among RA patients was significantly lower in comparison to controls (4.4 +/- 4.6 vs. 5.8 +/- 4.9 kPa(-1) x 10(-3), p = 0.04). A significant correlation was found between PWV and age (r = 0.67, p < 0.001), Framingham risk score (r = 0.61, p < 0.001), waist to hip ratio (r = 0.45, p < 0.001), systolic blood pressure (r = 0.37, p = 0.01), diabetes (r = 0.32, p = 0.001) and dyslipidemia (r = 0.32, p = 0.001). In multivariate analysis for the prediction of PWV, variables which were found significant included: RA (p = 0.01), age (p < 0.001) and hypertension (p = 0.01) for patients with RA and SLE (p = 0.02), waist to hip ratio (p < 0.001) and total cholesterol (p < 0.001) for patients with SLE. Arterial stiffness, characterized by metrics of aortic distensibility and pulse wave velocity derived from MRI, is increased in SLE and RA female patients.

• 出版日期2016-6