A novel cobalt(0) alkyne complex assisted "capture and release" strategy for oligosaccharide rapid assembly

作者:Liu, Yan-Bo; Yao, Wang; Meng, Shuai; Meng, Xiang-Bao; Li, Zhong-Jun*; Lou, Qing-Hua*
来源:Organic Chemistry Frontiers, 2018, 5(13): 2098-2102.
DOI:10.1039/c8qo00324f

摘要

A chromatographic purification free rapid oligosaccharide synthetic strategy was developed. The intermediates were conveniently purified by a new process based on a capture-release strategy on a resin that involved the Co-2(CO)(6)-PPh2/alkyne complex and the oxidated de-complex reaction. This method avoids the redundant multi-step classical chromatographic purification protocol and has been proved to be efficient by the synthesis of linear and branched penta-mannosides.

  • 出版日期2018-7-7
  • 单位北京大学; 天然药物与仿生药物国家重点实验室

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